WebJun 25, 1993 · DOI: 10.1016/S0040-4039(00)60515-4 Corpus ID: 98213134; Structural identity and stereochemical revision of polyoximic acid @article{Hanessian1993StructuralIA, title={Structural identity and stereochemical revision of polyoximic acid}, author={Stephen Hanessian and Jian-min Fu and Yongxue Tu and Kiyoshi Isono}, journal={Tetrahedron … WebBiosynthesis of the polyoxins, nucleoside peptide antibiotics. New metabolic role for L-isoleucine as a precursor for 3-ethylidene-L-azetidine-2-carboxylic acid (polyoximic acid). Biochemistry 1975, 14 (13) , 2992-2996.
Engineering of an industrial polyoxin producer for the rational ...
WebJul 17, 2024 · An artificial pathway for polyketide biosynthesis. Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies ... WebA gene cluster (pol) essential for the biosynthesis of polyoxin, a nucleoside antibiotic widely used for the control of phytopathogenic fungi, was cloned from Streptomyces cacaoi. A … iowa farm bureau spokesman classifieds
An artificial pathway for polyketide biosynthesis - Nature
WebThe biosynthesis of the unusual C-terminal amino acid of polyoxins, polyoximic acid, was also investigated with radiolabeled precursor feeding experiments. 100 The feeding and … WebThe biosynthetic origin of the carbon skeleton of 3-ethylidene-L-azetidine-2-carboxylic acid (polyoximic acid) is described. This unique cyclic amino acid is the C terminus of the nucleoside peptide antibiotics, the polyoxins, elaborated by … WebAug 18, 2016 · Polyoxin, produced by Streptomcyes cacaoi var. asoensis and Streptomyces aureochromogenes, contains two non-proteinogenic amino acids, carbamoylpolyoxamic acid (CPOAA) and polyoximic acid.Although the CPOAA moiety is highly unusual, its biosynthetic logic has remained enigmatic for decades. Here, we address CPOAA … iowa farm bureau member benefits