WebReflecting on its status as a founding STAT, both its structural and functional features are well conserved within this family ... For example, the Irf1−/− mouse embryonic fibroblasts (MEFs) are readily transformed by the Ha-ras oncogene owing a defect in apoptosis. Indeed, aberrations in IRF1 gene, owing to exon-skipping, ... WebNov 24, 2024 · DSBs activate STAT1 and STAT3 signalling, and IRF1 is required for DSB-dependent PD-L1 upregulation. Thus, our findings reveal the involvement of DSB repair in PD-L1 expression and provide...
IRF1 Gene - GeneCards IRF1 Protein IRF1 Antibody
WebDec 8, 2024 · Interferon regulatory factor-1 (IRF1) is a primary transcription factor responsible for PD-L1 induction via the IFN-γ-driven JAK/STAT–IRF1 signaling cascade. WebJan 21, 2024 · IRF1 is a molecule originally identified as a regulator of type I IFNs and critical for antiviral immune control, but it has also recently been involved in multiple inflammatory innate immune ... famous places to eat in cleveland
Targeting IFN/STAT1 Pathway as a Promising Strategy to
WebMay 9, 2024 · Activated phosphorylated STAT1 (pSTAT1) typically dimerizes with pSTAT2 to form the ISGF3 complex together with the interferon regulatory factor 9 (IRF9) ( Smith et al., 2005 ). This complex binds at the genomic level to the ISRE sequences to control a long list of interferon-induced genes ( Friedman and Stark, 1985 ). WebSTAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. There are two possible transcripts (due to alternative splicing) that encode 2 isoforms of STAT1. [7] [8] STAT1α, the full-length version of the protein, is the main active isoform, responsible for most of the known functions of STAT1. WebThe CellSensor® irf1-bla CTLL-2 cell line contains a beta-lactamase reporter gene under control of the interferon regulatory factor-1 (irf1) response element stably integrated into CTLL-2 cells. CTLL-2 cells are a clone of cytotoxic T cells derived from a C57/BL/6 mouse, which is cell-growth dependent on mouse IL-2. This cell line validated for IC famous places to eat in philadelphia